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Research paper published: Synthesis, Characterization, Antibacterial Properties, and In Vitro Studies of Selenium and Strontium Co-Substituted Hydroxyapatite.

The research was carried out by Dr. Muhammad Maqbool, under the supervision of Prof. Aldo Boccaccini (FAU Erlangen). 
Leiden, May 2021

CAM Bioceramics would like to congratulate Dr. Muhammad Maqbool, scientist at CAM Bioceramics and all co-authors on the publication of their research paper ”Synthesis, Characterization, Antibacterial Properties, and In Vitro Studies of Selenium and Strontium Co-Substituted Hydroxyapatite”.

Infections surrounding bone implants are an important challenge for advanced reconstructive surgery. Bacteria are becoming more resistant to drugs and there are fewer effective antibiotics to fight against pathogens. Antimicrobial resistance (AMR) can lead to implant exchange which causes pain to patients and are a burden on healthcare systems worldwide.

The work focused on tackling the worldwide threat posed by the rapid growth of antimicrobial resistance to antibiotics. Its aim to develop bioceramics having intrinsic antibacterial properties. The results highlight that the synergistic effect of selenium and strontium ions co-substituted in hydroxyapatite offers great potential in the design of novel antibacterial materials that provide antibacterial activity without the use of antibiotics, allowing them to be used as starting materials for the development of unique and effective antibacterial implants for bone regeneration.

“In line with CAM Bioceramics mission, to be the trusted partner for innovative calcium phosphate solutions and services worldwide, we are committed to support our customers to improve patients lives. Identifying and developing novel materials

Schermafbeelding 2021-06-17 om 14.23.05

 

for biomedical applications that can provide antibacterial properties without the use of any drugs, will significantly improve patients outcomes and reduce cost to society.

The paper can be found using the link below:
https://www.mdpi.com/1422-0067/22/8/4246

As communicated in November 2020 CAM Bioceramics is an industry partner and a work package leader of NWO funded DARTBAC Project. The DARTBAC project focuses specifically on developing and testing of the efficacy and safety of novel antimicrobial technologies for preventing & combatting infections.

Further information about the DARTBAC project can be found at: https://www.cambioceramics.com/news/dartbac-project-grant-approval-leiden-november-2020-2/

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Contact person:
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Kevin Hogeboom

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Giuseppe Cama
Muhammad Maqbool


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Products

CAM Bioceramics is a contract development and manufacturing company of Orthobiologic Calcium Phosphates. Our compositions are made from Hydroxyapatite, β-TCP, α-TCP and Biphasic HA/TCP.

Our products are available as coating powders, specialty powders, granules, blocks, and as excipients. Customized calcium phosphates are developed by our highly specialized engineers upon customer request.

 

Coating powder

 

 

  

Activities

r and d

Co-Development
Product development has a key role in our organization. Our specialized engineers develop customized products and revolutionary new biomaterials. As calcium phosphate experts, we assist industry leaders in finding the right product mix and up-scaling into production.

cleanroom

Customized Cleanroom Packaging
Our class-7 cleanrooms, bioburden measurements and excellently trained staff enable us to provide our clients with full-service, customized packaging activities.

 

coatings

HA Plasma-Sprayed Coating Services
CAM Bioceramics is a worldwide pioneer in HA plasma-sprayed coatings. We are specialized in the most challenging and demanding orthopedic and dental implants. 

Company Profile

In the 1980s, we were the first company to develop and commercially produce innovative HA plasma-sprayed coatings on orthopedic implants. Since then, our pioneering work has led to the worldwide adoption of hydroxyapatite coatings. HA Coating was the first step in the formation of what is now an established research, manufacturing, packaging and consultancy organization with an extensive portfolio of orthobiologic calcium phosphates.

As a dedicated contract development and manufacturing organization, we have set up robust processes to manufacture a wide range of products for industry leaders in the orthopedic, dental and aesthetic markets. Our offices and in-house production facilities are located in Leiden Bio Science Park, a leading life sciences cluster. Situated close to Amsterdam Schiphol Airport and other major European and global logistics hubs, we provide a highly reliable service to customers all over the world.

Quality

CAM Bioceramics provides calcium phosphates and related services that consistently meet customer needs and regulatory requirements applicable to medical devices and related services.

The CAM Bioceramics quality management system has been developed based on ISO 13485:2016.

Applications

Orthopedic implants
CAM Bioceramics’ powders are widely used in the orthopedic industry for plasma-sprayed implant coatings.

Bone graft substitutes
CAM Bioceramics calcium phosphate powders, granules, blocks and putties are used for synthetic bone grafts, as a filler for gaps and voids in the treatment of fractures and major bone defects.

Bioresorbable fixation
CAM Bioceramics calcium phosphate products are applied as material for bioresorbable fixation systems such as interference screws and suture anchors.

Dental
CAM Bioceramics specialized dental products include dental bone grafts and implant coatings.

Aesthetics 
CAM Bioceramics hydroxyapatite is used as an injectable dermal filler.




Excipients
CAM Bioceramics calcium phosphates are used as a carrier for active ingredients for a targeted delivery and controlled release.

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